Lene Secher Myrmel

Researcher

E-mail: LeneSecher.Myrmel@hi.no

Telephone: 99244177

Department: Sjømat og ernæring

Publications

Academic articles

2024

Are mesopelagic organisms nutritious food? Impact on metabolism, availability of nutrients, and contaminants from dietary intervention in C57BL/6J mice model

Atabak Mahjour Azad, Lene Secher Myrmel, Martin Wiech, Ole Jakob Nøstbakken, Even Fjære, Anne-Katrine Lundebye, Quang Tri Ho, Lise Madsen

Food Frontiers

2024

Dietary protein affects tissue accumulation of mercury and induces hepatic Phase I and Phase II enzyme expression after co-exposure with methylmercury in mice

Ragnhild Marie Mellingen, Josef Rasinger, Ole Jakob Nøstbakken, Lene Secher Myrmel, Annette Bernhard

Journal of Nutritional Biochemistry 133

2024

The Food Sources in Western Diets Modulate Obesity Development, Insulin Sensitivity, and the Plasma and Cecal Metabolome in Mice

Lene Secher Myrmel, Even Fjære, Mo Han, Benjamin Anderschou Hollbech Jensen, Ulrike Rolle-Kampczyk, Niels Banhos Danneskiold-Samsøe, Quang Tri Ho, Anita Smette, Martin von Bergen, Liang Xiao, Karstein Kristiansen, Lise Madsen

Molecular Nutrition & Food Research

2024

Intake of different types of seafood and meat and risk of type 2 diabetes in women: a prospective study supported by a dietary intervention in mice

Lene Secher Myrmel, Jannike Øyen, Anne Lise Brantsæter, Even Fjære, Karen Haugvaldstad, Kåre Inge Birkeland, Ottar Kjell Nygård, Karstein Berge Kristiansen, Grace M. Egeland, Lise Madsen

Scientific Reports 14

2024

Host-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Jaelle Caitlin Brealey, Miyako Kodama, Jacob Agerbo Rasmussen, Søren B. Hansen, Luisa Santos-Bay, Laurene Alicia Lecaudey, Martin Hansen, Even Fjære, Lene Secher Myrmel, Lise Madsen, Annette Bernhard, Harald Sveier, Karsten Kristiansen, M Thomas P Gilbert, Michael David Martin, Morten Tønsberg Limborg

mSystems

2023

Bioavailability of iodine from a meal consisting of sushi and a wakame seaweed salad—A randomized crossover trial

Inger Aakre, Inger Beate Tveit, Lene Secher Myrmel, Even Fjære, Simon Ballance, Hanne Rosendahl-Riise

Food Science & Nutrition p. 1-11

2023

ARTICLEBioavailability of iodine from a meal consisting of sushi and a wakame seaweed salad—A randomized crossover trial

Inger Aakre, Inger Beate Tveit, Lene Secher Myrmel, Even Fjære, Simon Ballance, Hanne Rosendal-Riise

Food Science & Nutrition p. 1-11

2023

Refined mackerel oil increases hepatic lipid accumulation and reduces choline and choline-containing metabolites in the liver tissue in mice fed a Western diet

Even Fjære, Lene Secher Myrmel, Josef Rasinger, Annette Bernhard, Livar Frøyland, Lise Madsen

Food Research International 173

2023

Metabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesity

Atabak Mahjour Azad, Annette Bernhard, Anne Shen, Lene Secher Myrmel, Anne-Katrine Lundebye, Laurene Alicia Lecaudey, Even Fjære, Quang Tri Ho, Harald Sveier, Karsten Kristiansen, Morten Tønsberg Limborg, Lise Madsen

Food Research International 169

2023

Blue Mussel (Mytilus edulis) and Blue Mussel-fed Salmon in a Mouse Model of Obesity

Food Research International 169

2022

Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice

Ragnhild Marie Mellingen, Lene Secher Myrmel, Josef Rasinger, Kai Kristoffer Lie, Annette Bernhard, Lise Madsen, Ole Jakob Nøstbakken

International Journal of Molecular Sciences 23

2022

Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima)

Even Fjære, Rikke Poulsen, Arne Duinker, Bjørn Liaset, Martin Hansen, Lise Madsen, Lene Secher Myrmel

Foods 11

2021

RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice

Ragnhild Marie Mellingen, Lene Secher Myrmel, Kai Kristoffer Lie, Josef Rasinger, Lise Madsen, Ole Jakob Nøstbakken

Metallomics 13 p. 1-12

2020

The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets

Even Fjære, Lene Secher Myrmel, Karianne Dybing, Ondrej Kuda, Benjamin Anderschou Holbech Jensen, Martin Rossmeisl, Livar Frøyland, Karsten Kristiansen, Lise Madsen

Nutrients 12 p. 1-19

2019

The impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese mice

Lene Secher Myrmel, Kristin Røen Fauske, Even Fjære, Annette Bernhard, Ulrike Liisberg, Astrid Elise Hasselberg, Jannike Øyen, Karsten Kristiansen, Lise Madsen

Nutrients 11:1153 p. 1-19

2019

One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects

Kari Merete Ersland, Lene Secher Myrmel, Even Fjære, Rolf Kristian Berge, Lise Madsen, Vidar Martin Steen, Silje Skrede

International Journal of Neuropsychopharmacology 22 p. 358-369

2019

Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice

Even Fjære, Lene Secher Myrmel, Ditte Olsen Lützhøft, Hanne Andersen, Jacob Bak Holm, Pia Kiilerich, Rita Hannisdal, Bjørn Liaset, Karsten Kristiansen, Lise Madsen

Journal of Nutritional Biochemistry 66 p. 98-109

2019

Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Anne-Marie Lundsgaard, Jacob Bak Holm, Kim Anker Sjøberg, Kirstine Nyvold Bojsen-Møller, Lene Secher Myrmel, Even Fjære, Benjamin Anderschou Holbech Jensen, Trine S. Nicolaisen, Janne R. Hingst, Sine L. Hansen, Sophia Doll, Philip Emanuel Geyer, Atul S. Deshmukh, Jens J. Holst, Lise Madsen, Karsten Kristiansen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens

Cell Metabolism 29 p. 50-63.e4

2018

Dietary Proteins, Brown Fat, and Adiposity

Lise Madsen, Lene Secher Myrmel, Even Fjære, Jannike Øyen, Karsten Kristiansen

Frontiers in Physiology 12

2018

Effects of frozen storage on phospholipid content in atlantic cod fillets and the influence on diet-induced obesity in mice

Kristin Røen Fauske, Annette Bernhard, Even Fjære, Lene Secher Myrmel, Livar Frøyland, Karsten Kristiansen, Bjørn Liaset, Lise Madsen

Nutrients 10:695 p. 1-17

2018

Subchronic dietary exposure to ethoxyquin dimer induces microvesicular steatosis in male BALB/c mice

Annette Bernhard, Josef Daniel Rasinger, Helene Wisløff, Øyvor Kolbjørnsen, Lene Secher Myrmel, Marc Berntssen, Anne-Katrine Lundebye, Robin Ørnsrud, Lise Madsen

Food and Chemical Toxicology 118 p. 608-625

2017

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

Anne-Marie Lundsgaard, Andreas M. Fritzen, Kim A. Sjøberg, Lene Secher Myrmel, Lise Madsen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens

Molecular Metabolism 6 p. 22-29

2017

Links between dietary protein sources, the gut microbiota, and obesity

Lise Madsen, Lene Secher Myrmel, Even Fjære, Bjørn Liaset, Karsten Kristiansen

Frontiers in Physiology 8

2017

Opposite regulation of insulin sensitivity by dietary lipid versus carbohydrate excess

Anne-Marie Lundsgaard, Kim A. Sjøberg, Louise D Høeg, Jacob Jeppesen, Andreas B Jordy, Annette K. Serup, Andreas M. Fritzen, Henriette Pilegaard, Lene Secher Myrmel, Lise Madsen, Jørgen F.P. Wojtaszewski, Erik A. Richter, Bente Kiens

Diabetes 66 p. 2583-2595

2017

Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression

Si Brask Sonne, Rachita Yadav, Guangliang Yin, Marlene D. Dalgaard, Lene Secher Myrmel, Ramneek Gupta, Jun Wang, Lise Madsen, Shingo Kajimura, Karsten Kristiansen

Adipocyte 6 p. 124-133

2016

Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice

Annette Bernhard, Marc Berntssen, Anne-Katrine L. Haldorsen, Anita Røyneberg Alvheim, Lene Secher Myrmel, Even Fjære, Bente Elisabeth Torstensen, Karsten Kristiansen, Lise Madsen, Trond Brattelid, Josef Daniel Rasinger

Food and Chemical Toxicology 97 p. 411-423

2016

Macronutrient composition determines accumulation of persistent organic pollutants from dietary exposure in adipose tissue of mice

Lene Secher Myrmel, Even Fjære, Lisa Kolden Midtbø, Annette Bernhard, Rasmus Koefoed Petersen, Si Brask Sonne, Alicja Mortensen, Qin Hao, Trond Brattelid, Bjørn Liaset, Karsten Kristiansen, Lise Madsen

Journal of Nutritional Biochemistry 27 p. 307-316

2016

Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice

Pia Kiilerich, Lene Secher Myrmel, Even Fjære, Qin Hao, Floor Hugenholtz, Si Brask Sonne, Muriel Derrien, Lone Møller Pedersen, Rasmus Koefoed Petersen, Alicja Mortensen, Tine Rask Licht, Maria Unni Rømer, Ulla Birgitte Vogel, Linn Jeanette Waagbø, Natasa Giallourou, Qiang Feng, Liang Xiao, Chuan Liu, Bjørn Liaset, Michiel Kleerebezem, Jun Wang, Lise Madsen, Karsten Kristiansen

American Journal of Physiology. Endocrinology and Metabolism 310 p. E886-E899

2016

Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice

Ulrike Liisberg, Kristin Røen Fauske, Ondrej Kuda, Even Fjære, Lene Secher Myrmel, Nina Cecilie Norberg, Livar Frøyland, Ingvild Eide Graff, Bjørn Liaset, Karsten Kristiansen, Jan Kopecký, Lise Madsen

Journal of Nutritional Biochemistry 33 p. 119-127

2016

The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice

Ulrike Liisberg, Lene Secher Myrmel, Even Fjære, Alexander Rønnevik, Susanne Bjelland, Kristin Røen Fauske, J Holm, Astrid L. Basse, JB Hansen, Bjørn Liaset, Karsten Kristiansen, Lise Madsen

Adipocyte 5 p. 196-211

2015

Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice

Even Fjære, Charlotte Andersen, Lene Secher Myrmel, Rasmus Koefoed Petersen, Jakob Bondo Hansen, Hanne Sørup Tastesen, Thomas Mandrup-Poulsen, Nils Brünner, Karsten Kristiansen, Lise Madsen, Maria Unni Rømer

PLOS ONE 10:e0132910

2013

Intake of Farmed Atlantic Salmon Fed Soybean Oil Increases Insulin Resistance and Hepatic Lipid Accumulation in Mice

Mohammad Madani Ibrahim, Lene Secher Myrmel, Ulrike Liisberg, Nina Sylvia Liland, Bente Elisabeth Torstensen, Trond Brattelid, Lise Madsen

PLOS ONE

2013

Intake of farmed atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice

Lisa Kolden Midtbø, Mohammad Madani Ibrahim, Lene Secher Myrmel, Ulrike Liisberg Aune, Anita Røyneberg Alvheim, Nina Sylvia Liland, Bente Elisabeth Torstensen, Grete Rosenlund, Bjørn Liaset, Trond Brattelid, Karsten Kristiansen, Lise Madsen

PLOS ONE 8

2012

High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice

Qin Hao, Haldis Haukås Lillefosse, Even Fjære, Lene Myrmel, Lisa Midtbø, Ragnhild Helene Jarlsby, Tao Ma, Bingbing Jia, Rasmus K. Petersen, Si Brask Sonne, Andre Chwalibog, Livar Frøyland, Bjørn Liaset, Karstein Kristiansen, Lise Madsen

American Journal of Physiology. Endocrinology and Metabolism 302 p. E1097-E1112

Scientific lectures

2022

Leveraging microbiota services through hologenomic analyses to improve gut health in farmed salmon

Jaelle Brealey, Miyako Kodama, Jacob A. Rasmussen, Søren B. Hansen, Luisa Santos-Bay, Martin Hansen, Even Fjære, Lene Secher Myrmel, Lise Madsen, Annette Bernhard, Karsten Kristiansen, Harald Sveier, Marcus Thomas Pius Gilbert, Michael David Martin, Morten T. Limborg

2019

The effect of selenomethionine on methylmercury accumulation in BALB/c mice

Ragnhild Marie Mellingen, Annette Bernhard, Ole Jakob Nøstbakken, Lene Secher Myrmel, Lise Madsen

2019

Subchronic dietary exposure to ethoxyquin dimer induces microvesicular steatosis in male BALB/c mice

Annette Bernhard, Josef Daniel Rasinger, Helene Wisløff, Øyvor Kolbjørnsen, Lene Secher Myrmel, Marc Berntssen, Anne-Katrine Lundebye, Robin Ørnsrud, Lise Madsen

2019

The effect of selenomethionine on methylmercury accumulation in BALB/c mice

Ragnhild Marie Mellingen, Ole Jakob Nøstbakken, Lene Secher Myrmel, Annette Bernhard, Lise Madsen

2016

Miljøgifter og fedme – Hvem er høna og hvor er egget?

Myrmel, L.S.

2016

Obesity development and macronutrient composition determine accumulation of persistent organic pollutants in mice

Myrmel, L.S.

2015

Sjømat: Slankende eller vektøkende?

Myrmel, L.S.

2014

Health effects of seafood on obesity and diabetes

Myrmel, L.S., Fjære, E.

Poster

2023

Interplay between host genome and microbiota during parasite infection in farmed Atlantic salmon

Jaelle C. Brealey, Miyako Kodama, Jacob A. Rasmussen, Søren B. Hansen, Luisa Santos-Bay, Martin Hansen, Even Fjære, Lene Secher Myrmel, Lise Madsen, Annette Bernhard, Karsten Kristiansen, Harald Sveier, Marcus Thomas Pius Gilbert, Michael David Martin, Morten Tønsberg Limborg

2022

Health effects, nutrients and undesirables availability from consumption of mesopelagic species in C57BL/6J mouse

Atabak Mahjour Azad, Lene Secher Myrmel, Martin Wiech, Even Fjære, Ole Jakob Nøstbakken, Lise Madsen

2017

Re-appearance of bacteria in antibiotic treated mice after exposure to methylmercury

Cecilie Smith Svanevik, Lene Secher Myrmel, Even Fjære, Amund Måge, Lise Madsen, Bjørn Tore Lunestad

2015

The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice

Myrmel, L.S., Liisberg, U., Fjære, E., Fauske, K.R., Basse, A.L., Hansen, J.B., Liaset, B., Kristiansen, K. and Madsen, L.

2015

Low fat diet combined with exercise reversed diet-induced obesity and increased UCP1 expression in iBAT

Fjære, E., Myrmel, L.S, Andersen, H., Hannisdal, R., Kristiansen, K and Madsen, L.

2014

The cardioprotective effect of the modern Atlantic salmon - dietary spillover from fish

Annette Bernhard, Josef Daniel Rasinger, LK Mitdbø, Lene Secher Myrmel, Bente Elisabeth Torstensen, K Kristiansen, Lise Madsen, Trond Brattelid

2013

alpha HBCD: Effect or no effect - A matter of diet?

Annette Bernhard, Lene Secher Myrmel, Lisa Kolden Mitbø, Mohammad Madani Ibrahim, Josef Daniel Rasinger, Bente Elisabeth Torstensen, Lise Madsen, Trond Brattelid

2012

High-glycemic index carbohydrates abrogate the anti-obesity effect of fish oil in mice

10. Myrmel, L.S., Hao, Q., Lillefosse, H.H., Fjaere, E., Midtbo, L.K., Jarlsby, R.H., Ma, T., Jia, B., Petersen, R.K., Sonne, S.B., et al.

Reports and dissertations

2022

HoloFish: use of microbiome-genome co-optimisation to improve gut-health and growth in farmed salmon

Brealey, J.C., Kodama M., Rasmussen, J.A., Hansen, S.B., Nielsen, L., Fjære, E., Hansen, M., Myrmel, L.S., Madsen, L., Kristiansen, K., Sveier, H., Gilbert, M.T.P., Martin, M.D., Limborg, M.T.

2020

Kartlegging av raffinert makrellolje til humant konsum – positive og negative helseeffekter ved inntak av raffinert makrellolje

Fjære, E., Myrmel, L.S., Madsen, L.

2017

Safe use of the antioxidant ethoxyquin in fish feed

3. Bernhard, A., Berntssen, M.H., Merel, S., Rasinger, Lundebye, A.K., Madsen, L. Myrmel, L.S., Ørnsrud, R.

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Lene Secher Myrmel

Publications

Academic articles

Are mesopelagic organisms nutritious food? Impact on metabolism, availability of nutrients, and contaminants from dietary intervention in C57BL/6J mice model

Dietary protein affects tissue accumulation of mercury and induces hepatic Phase I and Phase II enzyme expression after co-exposure with methylmercury in mice

The Food Sources in Western Diets Modulate Obesity Development, Insulin Sensitivity, and the Plasma and Cecal Metabolome in Mice

Intake of different types of seafood and meat and risk of type 2 diabetes in women: a prospective study supported by a dietary intervention in mice

Host-gut microbiota interactions shape parasite infections in farmed Atlantic salmon

Bioavailability of iodine from a meal consisting of sushi and a wakame seaweed salad—A randomized crossover trial

ARTICLEBioavailability of iodine from a meal consisting of sushi and a wakame seaweed salad—A randomized crossover trial

Refined mackerel oil increases hepatic lipid accumulation and reduces choline and choline-containing metabolites in the liver tissue in mice fed a Western diet

Metabolic effects of diet containing blue mussel (Mytilus edulis) and blue mussel-fed salmon in a mouse model of obesity

Blue Mussel (Mytilus edulis) and Blue Mussel-fed Salmon in a Mouse Model of Obesity

Dietary selenomethionine reduce mercury tissue levels and modulate methylmercury induced proteomic and transcriptomic alterations in hippocampi of adolescent BALB/c mice

Iodine Bioavailability and Accumulation of Arsenic and Cadmium in Rats Fed Sugar Kelp (Saccharina latissima)

RNA sequencing and proteomic profiling reveal different alterations by dietary methylmercury in the hippocampal transcriptome and proteome in BALB/c mice

The anti-obesogenic effect of lean fish species is influenced by the fatty acid composition in fish fillets

The impact of different animal-derived protein sources on adiposity and glucose homeostasis during ad libitum feeding and energy restriction in already obese mice

One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects

Effects of exercise and dietary protein sources on adiposity and insulin sensitivity in obese mice

Mechanisms Preserving Insulin Action during High Dietary Fat Intake

Dietary Proteins, Brown Fat, and Adiposity

Effects of frozen storage on phospholipid content in atlantic cod fillets and the influence on diet-induced obesity in mice

Subchronic dietary exposure to ethoxyquin dimer induces microvesicular steatosis in male BALB/c mice

Circulating FGF21 in humans is potently induced by short term overfeeding of carbohydrates

Links between dietary protein sources, the gut microbiota, and obesity

Opposite regulation of insulin sensitivity by dietary lipid versus carbohydrate excess

Obesity is associated with depot-specific alterations in adipocyte DNA methylation and gene expression

Marine fatty acids aggravate hepatotoxicity of α-HBCD in juvenile female BALB/c mice

Macronutrient composition determines accumulation of persistent organic pollutants from dietary exposure in adipose tissue of mice

Effect of a long-term high-protein diet on survival, obesity development, and gut microbiota in mice

Intake of a Western diet containing cod instead of pork alters fatty acid composition in tissue phospholipids and attenuates obesity and hepatic lipid accumulation in mice

The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice

Tissue inhibitor of matrix metalloproteinase-1 is required for high-fat diet-induced glucose intolerance and hepatic steatosis in mice

Intake of Farmed Atlantic Salmon Fed Soybean Oil Increases Insulin Resistance and Hepatic Lipid Accumulation in Mice

Intake of farmed atlantic salmon fed soybean oil increases insulin resistance and hepatic lipid accumulation in mice

High-glycemic index carbohydrates abrogate the antiobesity effect of fish oil in mice

Scientific lectures

Leveraging microbiota services through hologenomic analyses to improve gut health in farmed salmon

The effect of selenomethionine on methylmercury accumulation in BALB/c mice

Subchronic dietary exposure to ethoxyquin dimer induces microvesicular steatosis in male BALB/c mice

The effect of selenomethionine on methylmercury accumulation in BALB/c mice

Miljøgifter og fedme – Hvem er høna og hvor er egget?

Obesity development and macronutrient composition determine accumulation of persistent organic pollutants in mice

Sjømat: Slankende eller vektøkende?

Health effects of seafood on obesity and diabetes

Poster

Interplay between host genome and microbiota during parasite infection in farmed Atlantic salmon

Health effects, nutrients and undesirables availability from consumption of mesopelagic species in C57BL/6J mouse

Re-appearance of bacteria in antibiotic treated mice after exposure to methylmercury

The protein source determines the potential of high protein diets to attenuate obesity development in C57BL/6J mice

Low fat diet combined with exercise reversed diet-induced obesity and increased UCP1 expression in iBAT

The cardioprotective effect of the modern Atlantic salmon - dietary spillover from fish

alpha HBCD: Effect or no effect - A matter of diet?

High-glycemic index carbohydrates abrogate the anti-obesity effect of fish oil in mice

Reports and dissertations

HoloFish: use of microbiome-genome co-optimisation to improve gut-health and growth in farmed salmon

Kartlegging av raffinert makrellolje til humant konsum – positive og negative helseeffekter ved inntak av raffinert makrellolje

Safe use of the antioxidant ethoxyquin in fish feed

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