Eystein Oveland
Arbeidsområde
SmartLabHI
I am leading the project SmartLabHI, a transformation project in line with the new IMR strategy, aiming at streamlining laboratory operations focusing on the accredited analyses to optimize the deliveries.
Vitamin research
I am leading a project, Vitaminomics, on modernization of methods for vitamin analyses of food and feed, taking advantage of my expertise in HPLC and mass spectrometry for identification and quantification of compounds in biological- and biomedical sciences.
Recent work include method establishment at IMR of an LC-MS/MS method for simultaneous determination of vit B1, B2, B3, B6 (and soon B7), an immunoaffinity LC-UV method for vit B12 analysis (AOAC/ISO), and an LC-MS/MS method to determine folate based on 6 different vitamin forms (modified from AOAC/NMKL).
Standardization work
I am an expert member in working groups for vitamins and other nutrients in the standardization organizations CEN and ISO, and participate in development of standardized methods in food chemistry through AOAC and as executive director of NMKL.
Researcher profile in ResearchGate
Curriculum Vitae
Employment
2018 Jan – Senior Researcher (Research professor, 1183). Institute of Marine Research (IMR).
2022 Aug – Executive Director. Nordic-Baltic Committee on Food Analysis (NMKL).
2020 – 2022 Secretary General. Nordic Committee on Food Analysis (NMKL).
2016 – 2017 Senior Scientist (Research professor 1183 from 2017). The National Institute of Nutrition and Seafood Research (NIFES).
2012 – 2016 Researcher (1109). The Department of Clinical Medicine (K1) and the Proteomics Unit at the University of Bergen (PROBE), Department of Biomedicine (IBM), Faculty of medicine and Dentistry (MOFA), University of Bergen (UiB): ”Identification of biomarkers to define the cause of multiple sclerosis”.
2011 – 2012 Researcher (1109). PROBE, UiB, 3 months.
2008 – 2011 Post Doc. Project: “The extracellular microenvironment”, the Cardiovascular Research Group, IBM, MOFA, UiB.
2003 – 2004 Researcher. PROBE, UiB.
2002 – 2003 Researcher. UniTargetingResearch AS (R&D), 50-100%.
Education
2004 – 2008 PhD, thesis: “Modulation of apoptosis by the receptor tyrosine kinase Flt3 in acute myeloid leukemia cells”, Institute for Biomedicine/Proteomics Unit, Faculty of Medicine, University of Bergen.
2000 – 2003 Cand. scient. (Master’s degree), thesis: "The use of marine luciferases in a study aiming at the secretion of intracellular proteins from mammalian cells", the Department of Molecular Biology, UiB.
1996 – 1999 Høgskolekandidat (similar to Bachelor), thesis: ”Mikrotubers on potato plants; induction conditions, regeneration ability and genetic transformation”, The Biotechnology Section, Hedmark University College.
Commissions
2023 Oct – Proteomics Unit UiB (PROBE) Advisory Board member.
2023 Feb – MicroVal (Board member).
2022 Feb – AOAC International - Europe Section Board member.
2021 Jan – NordVal International Board member.
2017 Feb – Comitè Europeèn de Normalisation (CEN) Technical Committee (TC) Working Group (WG) Analytical Standards on Vitamins (CEN/TC 275/WG 9) (Expert member).
2017 Feb – ISO/TC 34/WG 14 Vitamins, carotenoids and other nutrients (Expert member).
2017 Feb – AOAC International (Expert member), participate in stakeholder and expert review panel meetings on multi laboratory testing for analytical methods for vitamins.
2009 – 2011 Representative for temporary scientific employees in the institute council at IBM, UiB.
2007 – 2008 Representative for temporary scientific employees in the institute research council at IBM, UiB.
2006 – 2007 Representative for temporary scientific employees in the faculty research council, MOFA, UiB.
Presentations at scientific meetings (last 7 years)
17th Baltic Conference on Food Science and Technology FOODBALT 2024 “SUSTAINABLE FOOD PRODUCTION – A CHALLENGE FOR THE WHOLE PRODUCTION CHAIN”. Talk: “Nordic-Baltic Committee on Food Analysis: Current Activities, Validation of Methods, and Application of Mass Spectrometry”. 2024.
Int. Vitamin Conference, Copenhagen, Denmark. Talk: “LC-ESI-MS/MS method for simultaneous determination of the B-vitamins B1, B2, B3, B5 and B6 in feed and food. Oane ZM, Bøkevoll A, Petrova S, Myhra T, Oveland E. 2023.
16th Baltic Conference on Food Science and Technology FOODBALT 2023 “TRADITIONAL MEETS NON-TRADITIONAL IN FUTURE FOOD”. Invited keynote lecture with presentation: “NMKL and validation of methods for food analysis – Examples from determination of vitamins using LC-MS/MS”. Scientific committee member and conference session co-moderator. 2023.
Int. Vitamin Conference, Copenhagen, Denmark. Poster and presentation: “UHPLC-MS/MS determination of total folate by quantification of 6 vitamers -current challenges. Oveland E, Petrova SM, Myhra T, Bøkevoll A, Waagbø R. Conference session co-moderator. 2021.
Norske Seminar i Massespektrometri Bi-annual Meeting, Hafjell. Poster: “Quantification of Folates in Salmon using UHPLC-MS/MS”. Oveland E, Hageskal R, Wollertsen N, Mommens M, Waagbø R, Skjaerven KH. Poster prize. 2019.
AOAC Annual Meeting, Toronto, Canada. Poster: “Salmon Production and Quantification of Folates Using AOAC Trienzyme UPLC-MS/MS Method”. Oveland E, Hageskal R, Samori E, Wollertsen N, Mommens M, Waagbø R, Skjaerven KH. 2018.
AOAC Annual Meeting , Atlanta, USA. Poster: “Method development and analysis of vit K (phylloquinone and menaquinones) in selected foods”. Oveland E, Rød KE, Bøkevoll A, Dahl L, Hamre K, Waagbø R. 2017.
AOAC SPIFAN and ISO WG 14 Midyear Meeting, Gaithersburg, Maryland, USA. Representant for Standard Norge i ISO WG 14. 2017.
Project lead
2024 – SmartLabHI (IMR project), in line with the new IMR strategy the project will coordinate the transformation of the IMR laboratory operations with focus on the accredited analyses to streamline and modernize the deliveries.
2020 – NMKL.org and different projects within NMKL.
2017 – Vitaminomics (IMR project).
2018 – 2019 Metodeutvikling Nansen, prøvebehandling og lagring (IMR project).
2012 – 2016 Brain tissue proteomics project, KG Jebsen Centre for Multiple Sclerosis Research, Department of Clinical Medicine (UiB project).
2008 – 2011 Ovarian cancer and tissue physiology proteomics and mass spectrometry projects, Heart and Circulatory research group (UiB project).
Supervision of students
2024 Co-supervisor PhD: “Proteomics and immunohistochemistry to detect lesion stage markers in multiple sclerosis”, Ahmad IM, MOFA, UiB.
2021 Co-supervisor PhD: “Using meta-analyses of proteomics data to identify novel disease networks in multiple sclerosis”, Lereim RR, MOFA, UiB.
2014 Main supervisor master: “Proteomics of human brain and CSF to detect biomarkers in multiple sclerosis” Reehorst Lereim R, MOFA, UiB.
2013 Co-supervisor PhD: “The microenvironment in human ovarian carcinoma – characterization through proteomic analysis of tissue interstitial fluid”, Haslene-Hox H, MOFA, UiB.
2011 Co-supervisor master: “Proteinuria: A new approach to understand glomerular barrier function using quantitative proteomics”, Wallace PW, MOFA, UiB.
2010 Co-supervisor medical Student Research Programme: ”Identification of tumor-specific proteins in ovarian cancer”, Sværen MK and Naterstad IK, MOFA, UiB.
2006 Co-supervisor master: ”Approaches to discover members of the oncogenic Flt3 receptor tyrosine kinase signaling network”, Hodneland LI, MOFA, UiB.
University examiner and teaching
2020 External examiner master’s degree: Chemistry Department, UiB.
2020 External examiner master’s degree: Centre for International Health Department of Global Health and Primary Care, UiB.
2017 – 19 External examiner (3 times): Biomedical Nutrition Physiology (BMED 381), IBM, UiB.
2006 – 08 Assistant teacher: medical students in particular subjects in Histology (1st year) and Anatomy (2nd year), MOFA, UiB.
2005 – 06 Teacher and course responsible (2 years): HUCEL 370 Apoptose, MOFA, UiB.
Organizer of meetings
2024 Sept NMKL-NordVal International Workshop on Validation and Certification of Alternative Methods for Food Analysis, Vilnius, Lithuania.
2023 Sept NMKL Annual Meeting as joint physical and virtual, Stockholm, Sweden.
2023 Aug NMKL Workshop on MALDI-TOF and Vibrio spp., IMR, Norway.
2023 May NMKL-NordVal International Steering Group Meeting, IMR, Norway.
2022 Aug NMKL Annual Meeting as joint physical and virtual, Seinäjoki, Finland.
2021 Aug NMKL Annual Meeting as joint physical and virtual, Jevnaker, Norway.
2019 May CEN/TC 275/WG 9 and ISO/TC/WG 14 joint meeting hosted by IMR, Bergen, Norway.
Scientific responsible for analytical methods at IMR
15 analytical methods for vitamin determination, 10 accredited by NA.
Publikasjoner
Vitenskapelige artikler (NVI)
2023
An Association of Chitinase-3 Like-Protein-1 With Neuronal Deterioration in Multiple Sclerosis
ASN Neuro
15
2022
Vitamin K (phylloquinone and menaquinones) in foods – Cost-effective quantification by LC-ESI-MS/MS
Food Chemistry
385
2022
Shotgun proteomics approaches for authentication, biological analyses, and allergen detection in feed and food-grade insect species
Food Control
137
p. 1-11
2022
Earlier or delayed seasonal broodstock spawning changes nutritional status and metabolic programming of growth for next-generation Atlantic salmon
Aquaculture
554
p. 1-14
2021
Inter-laboratory study on the detection of bovine processed animal protein in feed by LC-MS/MS-based proteomics
Food Control
125
2021
Proteoglycans contribute to the functional integrity of the glomerular endothelial cell surface layer and are regulated in diabetic kidney disease
Scientific Reports
11
2021
A higher proportion of ermin-immunopositive oligodendrocytes in areas of remyelination
PLOS ONE
16
p. 1-16
2021
Cuprizone and EAE mouse frontal cortex proteomics revealed proteins altered in multiple sclerosis
Scientific Reports
11
2020
Out-of-season spawning affects the nutritional status and gene expression in both Atlantic salmon female broodstock and their offspring
Comparative Biochemistry and Physiology A
247
2020
Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model
Journal of Neuroimmunology
339
2020
Collaborative study: Quantification of total folate in food using an efficient single-enzyme extraction combined with LC-MS/MS
Food Chemistry
333
p. 1-10
2019
Fingolimod downregulates brain sphingosine-1-phosphate receptor 1 levels but does not promote remyelination or neuroprotection in the cuprizone model
Journal of Neuroimmunology
339
2018
Novel protein signatures suggest progression to muscular invasiveness in bladder cancer
PLOS ONE
13:e0206475
p. 1-15
2017
Quantitative proteomics analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153
Aquatic Toxicology
185
p. 19-28
2017
Epac1-deficient mice have bleeding phenotype and thrombocytes with decreased GPIbβ expression
Scientific Reports
7:8725
p. 1-15
2017
Fast hyperbaric decompression after heliox saturation altered the brain proteome in rats
PLOS ONE
12
p. 1-16
2017
1,25-Dihydroxyvitamin-D3 induces brain proteomic changes in cuprizone mice during remyelination involving calcium proteins
Neurochemistry International
112
p. 262-277
2016
Quantitative analyses of the hepatic proteome of methylmercury-exposed Atlantic cod (Gadus morhua) suggest oxidative stress-mediated effects on cellular energy metabolism
BMC Genomics
17:554
p. 1-15
2016
CSF-PR 2.0: an interactive literature guide to quantitative cerebrospinal fluid mass spectrometry data from neurodegenerative disorders
16
p. 300-309
2016
The Brain Proteome of the Ubiquitin Ligase Peli1 Knock-Out Mouse during Experimental Autoimmune Encephalomyelitis
2015
Extracellular matrix composition affects rat skin distribution volume of plasma proteins with different size and charge
American Journal of Physiology. Heart and Circulatory Physiology
308
p. H29-H38
2015
Distribution volume of macromolecules in human ovarian and endometrial cancers - effects of extracellular matrix structure
American Journal of Physiology. Heart and Circulatory Physiology
308
p. H18-H28
2015
Viewing the proteome: How to visualize proteomics data?
Proteomics
15
p. 1341-1355
2015
Cerebrospinal fluid proteomics in multiple sclerosis
Biochimica et Biophysica Acta - Proteins and Proteomics
1854
p. 746-756
2014
In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR)
Molecular & Cellular Proteomics
13
p. 3152-3163
2014
In-depth characterization of the cerebrospinal fluid (CSF) proteome displayed through the CSF proteome resource (CSF-PR)
13
p. 3152-3163
2013
Increased WD-repeat containing protein 1 in interstitial fluid from ovarian carcinomas shown by comparative proteomic analysis of malignant and healthy gynecological tissue
Biochimica et Biophysica Acta - Proteins and Proteomics
1834
p. 2347-2359
2012
Ectopic expression of Flt3 kinase inhibits proliferation and promotes cell death in different human cancer cell lines
Cell Biology and Toxicology
28
p. 201-212
2012
Proteomic Evaluation of Inflammatory Proteins in Rat Spleen Interstitial Fluid and Lymph during LPS-Induced Systemic Inflammation Reveals Increased Levels of ADAMST1
Journal of Proteome Research
11
p. 5338-5349
2011
A new method for isolation of interstitial fluid from human solid tumors applied to proteomic analysis of ovarian carcinoma tissue
PLOS ONE
6
2011
The glomerular endothelial cell coat is essential for glomerular filtration
Kidney International
79
p. 1322-1330
2010
Isolation of interstitial fluid in skin during volume expansion: evaluation of a method in pigs
American Journal of Physiology. Heart and Circulatory Physiology
299
p. H1546-H1553
2009
Epac-induced Alterations in the Proteome of Human SH-SY5Y Neuroblastoma Cells
p. 244-245
2009
Ligand-induced Flt3-downregulation modulates cell death associated proteins and enhances chemosensitivity to idarubicin in THP-1 acute myeloid leukemia cells
Leukemia Research
33
p. 276-287
2006
Proteomics approaches to elucidate oncogenic tyrosine kinase signaling in myeloid malignancies
Current Pharmaceutical Biotechnology
7
p. 185-198
Annet tidsskriftbidrag
2015
PeptideShaker enables reanalysis of MS-derived proteomics data sets
Nature Biotechnology
33
p. 22-24
2012
A LOOK BEYOND BLOOD IN THE UREMIC SYNDROME: COMPARATIVE ANALYSIS OF INTERSTITIAL FLUID AND PLASMA IN KIDNEY DISEASE
Nephrology, Dialysis and Transplantation
27
p. 48-48
2010
ISOLATION AND IDENTIFICATION OF INFLAMMATORY SPECIFIC PROTEINS IN INTERSTITIAL FLUID IN SKIN DURING ACUTE OVERHYDRATION
Intensive Care Medicine
36
p. S407-S407
2008
FLT3 internal tandem duplication involving its libiquitin dependent endocytosis motif suspend modulation by HDM2 and are associated with inferior survival in AML
Haematologica
93
p. 10-10
2007
Flt3 mutations in proximity to an ubiquitin dependent endocytosis motif suspend its Hdm2 modulation
Blood
110
p. 148B-148B
Faglige foredrag
2021
Påvirker endret gytetidspunkt neste generasjon?
2018
A possible connection between oxidative stress and production related diseases in Atlantic salmon (Salmo salar L)
2018
Surveillance of microplastics (MPs) in seafood. Ongoing activity and future perspectives. Poster Presentation
2018
Microplastics in Seafood – An Overview of Surveillance and Analytical Activities at the Institute of Marine Research
2017
Integrative transcriptome and proteome analysis reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with PCB 153
2016
Integrative -omics analyses reveal perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) exposed to the persistent organic pollutant PCB 153
Poster
2016
Integrated analysis of transcriptome and proteome reveals perturbation of lipid metabolic pathways in the liver of Atlantic cod (Gadus morhua) treated with the persistent organic pollutant PCB 153
2007
Flt3 Mutations in Proximity to an Ubiquitin Dependent Endocytosis Motif Suspend Its Hdm2 Modulation
2004
Flt3 and HDM2 are reciprocally regulated through phosphorylation and ubiquitination in acute myelogenous leukaemia
Rapporter og avhandlinger
2019
Oksidativt stress, vårdropp i pigmentering og produksjonslidelser hos laks
2018
Pyrolysis-GC-Orbitrap MS - a powerful analytical tool for identification and quantification of microplastics in a biological matrix
2014
Establishment and usage of quantitative brain proteomics to investigate the role of Peli1 E3 ubiquitin ligase in the EAE mouse model of multiple sclerosis
2011
An in vivo study of the glomerular sieving of endogenous proteins in rats
2008
Modulation of apoptosis by the receptor tyrosine kinase Flt3 in acute myeloid leukemia cells
2006
Approaches to discover members of the oncogenic Flt3 receptor tyrosine kinase signaling network
2003
The use of marine luciferases in a study aiming at the secretion of intracellular proteins from mammalian cells
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