Erik Kjærner-Semb

Researcher

E-mail: erikkj@hi.no

Telephone: 93815437

Department: Reproduksjon og utviklingsbiologi

Publications

Academic articles

2024

Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification

Ross Fisher Cairnduff, Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Monica Favnebøe Solberg, Eva Andersson, Craig Primmer, William Perry, Kevin Alan Glover, Anna Sofie Troedsson Wargelius

BMC Genomic Data 25

2024

Loss of bmp15 function in the seasonal spawner Atlantic salmon results in ovulatory failure

Diego Crespo, Per Gunnar Fjelldal, Tom Johnny Hansen, Erik Nordtorp Kjærner-Semb, Kai Ove Skaftnesmo, Anders Thorsen, Birgitta Norberg, Rolf Brudvik Edvardsen, Eva Andersson, Rüdiger W. Schulz, Anna Wargelius, Lene Kleppe

The FASEB Journal 38

2024

Highly efficient in vivo C-to-T base editing in Atlantic salmon (Salmo salar) – A step towards aquaculture precision breeding

Mari Torsdotter Raudstein, Anne Hege Straume, Erik Nordtorp Kjærner-Semb, Morten Barvik, Ståle Ellingsen, Rolf Brudvik Edvardsen

Aquaculture 581

2024

Loss of Fshr Prevents Testicular Maturation in Atlantic Salmon (Salmo salar L.)

Eva Andersson, Rüdiger W. Schulz, Fernanda Almeida, Lene Kleppe, Kai Ove Skaftnesmo, Erik Nordtorp Kjærner-Semb, Diego Crespo, Per Gunnar Fjelldal, Tom Johnny Hansen, Birgitta Norberg, Rolf Brudvik Edvardsen, Anna Wargelius

Endocrinology 165

2023

In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.)

Mari Torsdotter Raudstein, Erik Nordtorp Kjærner-Semb, Morten Barvik, Silje Broll, Anne Hege Straume, Rolf Brudvik Edvardsen

Transgenic research

2022

Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut

Rolf Brudvik Edvardsen, Ola Wallerman, Tomasz Furmanek, Lene Kleppe, Patric Jern, Andreas Wallberg, Erik Nordtorp Kjærner-Semb, Stig Mæhle, Sara Olausson, Elisabeth Sundström, Torstein Harboe, Ragnfrid Mangor-Jensen, Margareth Møgster Drønen, Prescilla Perrichon, Birgitta Norberg, Carl-Johan Rubin

PLoS Genetics 18

2022

Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies

Diego Crespo, Kai Ove Skaftnesmo, Erik Nordtorp Kjærner-Semb, Ozlem Yilmaz, Birgitta Norberg, Sara Olausson, Petra Vogelsang, Jan Bogerd, Lene Kleppe, Rolf Brudvik Edvardsen, Eva Andersson, Anna Wargelius, Tom Johnny Hansen, Per Gunnar Fjelldal, Rüdiger W. Schulz

Frontiers in Endocrinology 13

2022

Full production cycle performance of gene-edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition

Lene Kleppe, Per Gunnar Fjelldal, Eva Andersson, Tom Johnny Hansen, Monica Sanden, Aina Bruvik, Kai Ove Skaftnesmo, Tomasz Furmanek, Erik Nordtorp Kjærner-Semb, Diego Crespo, Simon Flavell, Audun Østby Pedersen, Petra Vogelsang, Anja Torsvik, Karen Anita Kvestad, Sara Olausson, Birgitta Norberg, Rüdiger W. Schulz, J. Bogerd, N. Santi, Rolf Brudvik Edvardsen, Anna Wargelius

Aquaculture 560

2021

Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors

Anne Hege Straume, Erik Nordtorp Kjærner-Semb, Kai Ove Skaftnesmo, Hilal Guralp, Simon Lillico, Anna Wargelius, Rolf Brudvik Edvardsen

BMC Genomics 22

2020

Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon

Hilal Guralp, Kai Ove Skaftnesmo, Erik Nordtorp Kjærner-Semb, Anne Hege Straume, Lene Kleppe, Rüdiger W. Schulz, Rolf Brudvik Edvardsen, Anna Wargelius

Scientific Reports 10

2020

Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere

Erik Nordtorp Kjærner-Semb, Rolf Brudvik Edvardsen, Fernando Ayllon, Petra Vogelsang, Tomasz Furmanek, Carl-Johan Rubin, Alexey E. Veselov, Tom Ole Nilsen, Stephen D. McCormick, Craig R. Primmer, Anna Wargelius

Evolutionary Applications p. 1-16

2020

Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon

Anne Hege Straume, Erik Nordtorp Kjærner-Semb, Kai Ove Skaftnesmo, Hilal Guralp, Lene Kleppe, Anna Wargelius, Rolf Brudvik Edvardsen

Scientific Reports 10

2019

The influence of vgll3 genotypes on sea age at maturity is altered in farmed mowi strain Atlantic salmon

Fernando Ayllon, Monica Favnebøe Solberg, Kevin Glover, Faezeh Mohammadi, Erik Nordtorp Kjærner-Semb, Per Gunnar Fjelldal, Eva Andersson, Tom Johnny Hansen, Rolf Edvardsen, Anna Wargelius

BMC Genetics 20:44 p. 1-8

2018

Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis

Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Lene Kleppe, Elin Sørhus, Kai Ove Skaftnesmo, Tomasz Furmanek, Frida Thyri Segafredo, Anders Thorsen, Per Gunnar Fjelldal, Tom Johnny Hansen, Geir Lasse Taranger, Eva Andersson, Rüdiger W. Schulz, Anna Wargelius, Rolf Edvardsen

Scientific Reports 8:1912 p. 1-11

2016

Atlantic salmon populations reveal adaptive divergence of immune related genes - A duplicated genome under selection

Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Tomasz Furmanek, Vidar Wennevik, Geir Dahle, Eero Niemelä, Mikhail Ozerov, Juha-Pekka Vähä, Kevin Glover, Carl J. Rubin, Anna Wargelius, Rolf Edvardsen

BMC Genomics 17:610 p. 1-12

2015

The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon(Salmo salar L.) Males

Fernando Ayllon, Erik Nordtorp Kjærner-Semb, Tomasz Furmanek, Vidar Wennevik, Monica Favnebøe Solberg, Geir Dahle, Geir Lasse Taranger, Kevin Glover, Markus Sällman Almén, Carl J. Rubin, Rolf Edvardsen, Anna Wargelius

PLoS Genetics 11:e1005628

Other journal contributions

2021

Author Correction: Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon (Scientific Reports, (2020), 10, 1, (18042), 10.1038/s41598-020-74876-2)

Hilal Güralp, Kai Ove Skaftnesmo, Erik Nordtorp Kjærner-Semb, Anne Hege Straume, Lene Kleppe, Rüdiger W. Schulz, Rolf Brudvik Edvardsen, Anna Wargelius

Scientific Reports 11

2016

Ulik laks i sør og nord

Erik Nordtorp Kjærner-Semb, Anna Wargelius, Rolf Edvardsen

Dagens næringsliv

Scientific lectures

2024

Knockout av vgll3 gir sein kjønnsmodning i hannlaks

Kjærner-Semb, Erik Nordtorp

2024

Uses of biotechnology to control reproduction in Atlantic salmon

Lene Kleppe, Anna Sofie Troedsson Wargelius, Diego Crespo, Erik Nordtorp Kjærner-Semb, Kai Ove Skaftnesmo, Eva Andersson, Per Gunnar Fjelldal, Tom Johnny Hansen, Rolf Brudvik Edvardsen, Anders Thorsen, Rüdiger W. Schulz, Anne Torsvik, Grethe Beate Thorsheim, Anne Hege Straume, Petra Vogelsang, Ivar Helge Matre, Ann-Kathrin Jakobsen Kroken, Lise Dyrhovden, Audun Østby Pedersen, Simon Flavell, Florian Sambraus, Arnor Gullanger, Tone Knappskog

2024

Moving sterile Crispr salmon from the tank to sea cages - regulatory barriers and social impacts

Anna Sofie Troedsson Wargelius, Erik Nordtorp Kjærner-Semb, Anne Hege Straume, Per Gunnar Fjelldal, Jonatan Nilsson, Hilal Guralp, Kai Ove Skaftnesmo, Dorothy Jane Dankel, Eva Andersson, Lene Kleppe, Rolf Brudvik Edvardsen

2024

LACK OF VGLL3A DELAYS ONSET OF MALE MATURATION IN ATLANTIC SALMON

Kjærner-Semb, Erik Nordtorp

2024

Lack of vgll3a Delays Onset of Male Maturation in Atlantic Salmon

Kjærner-Semb, Erik Nordtorp

2023

Compensatory mechanism of NKAα1a in nkaα1b1/b2 Crispants during smoltification in Atlantic Salmon (Salmo salar)

Ross Fisher Cairnduff, Tom Ole Nilsen, Anna Sofie Troedsson Wargelius, Elsa Denker, Stephen D. McCormick, Erik Nordtorp Kjærner-Semb

2023

Lack of vgll3a delays onset of sexual maturation in Atlantic salmon (Salmo salar) males

Kjærner-Semb, Erik Nordtorp

2022

Kan genetiske tilpasninger i ferskvannlaks, avsløre genetikk bak smoltifisering?

Ross Fisher Cairnduff, Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Eva Andersson, Monica Favnebøe Solberg, Craig Primmer, Kevin Alan Glover, Anna Sofie Troedsson Wargelius

2022

Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification.

Ross Fisher Cairnduff, Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Eva Andersson, Monica Favnebøe Solberg, Kevin Alan Glover, Anna Sofie Troedsson Wargelius

2022

VGLL3A ALLELES AFFECT THE BRAIN-PITUITARY-GONAD AXIS IN ATLANTIC SALMON (SALMO SALAR) VIA REGULATION OF FSHB

Kjærner-Semb, Erik Nordtorp

2021

Functional genomic analysis of landlocked Atlantic salmon (Salmo Salar) populations.

Ross Fisher Cairnduff, Erik Nordtorp Kjærner-Semb, Eva Andersson, C. R. Primmer, William Bernard Perry, Anna Sofie Troedsson Wargelius

2021

Development of gene editing technology and applications in Atlantic salmon

Kjærner-Semb, Erik Nordtorp

2020

Hva er de genetiske forskjellene mellom ferskvannslaks og anadrom laks?.

Erik Nordtorp Kjærner-Semb, Rolf Brudvik Edvardsen, Fernando Ayllon, Tomasz Furmanek, Carl Johan Rubin, Tom Ole Nilsen, Vidar Wennevik, Craig Primmer, Anna Sofie Troedsson Wargelius

2019

Genomic regions under selection in landlocked Atlantic salmon. International Conference on Integrative Salmonid Biology

Erik Nordtorp Kjærner-Semb, Rolf Brudvik Edvardsen, Fernando Ayllon, Tomasz Furmanek, Carl-Johan Rubin, Vidar Wennevik, Tom Ole Nilsen, Craig Primmer, Anna Sofie Troedsson Wargelius

2019

Highly efficient CRISPR/Cas9 knock-in in Atlantic salmon

Rolf Brudvik Edvardsen, Anne Hege Straume, Erik Nordtorp Kjærner-Semb, hilal guralp, Lene Kleppe, Kai Ove Skaftnesmo, Anna Wargelius

2019

Genomic regions under selection in landlocked Atlantic salmon

Erik Nordtorp Kjærner-Semb, Rolf Brudvik Edvardsen, Fernando Ayllon, Tomasz Furmanek, Carl Johan Rubin, Vidar Wennevik, Tom Ole Nilsen, Stephen McCormic, Craig Primmer, Anna Wargelius

2018

Hvordan fungerer laksens pubertetsgen?

2016

Genome resequencing of geographically distinct Atlantic Salmon (Salmo salar) populations reveals adaptive divergence

Rolf Edvardsen, Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Tomasz Furmanek, Vidar Wennevik, Geir Dahle, Eero Niemelä, Mikhail Ozerov, Juha-Pekka Vähä, Kevin Glover, Carl Johan Rubin, Anna Wargelius

2016

Adaptive plasticity in Atlantic salmon- genetic predisposition of time at maturity and environmental triggers

Rolf Edvardsen, Erik Nordtorp Kjærner-Semb, Fernando Ayllon, Tomasz Furmanek, Tom Johnny Hansen, Per Gunnar Fjelldal, Carl Johan Rubin, Lene Kleppe, Kai Ove Skaftnesmo, Elin Sørhus, Faezeh Mohammadi, Geir Dahle, Vidar Wennevik, Monica Favnebøe Solberg, Kevin Glover, Birgitta Norberg, Geir Lasse Taranger, Eva Andersson, Rüdiger W. Schulz, Anna Wargelius

2015

The vgll3 locus controls time of maturation in salmon

Kjærner-Semb, Erik Nordtorp

2014

Mario: Interactive Tuning of Biological Analysis Pipelines Using Iterative Processing

Martin Ernstsen, Erik Nordtorp Kjærner-Semb, Nils Peder Willassen, Lars Ailo Bongo

Poster

2022

VGLL3A PÅVIRKER HJERNE-HYPOFYSE-GONADE AKSEN I ATLANTISK LAKS (SALMO SALAR) VIA REGULERING AV FSHB

Kjærner-Semb, Erik Nordtorp

2022

VGLL3A CONNECTS TO THE ATLANTIC SALMON (SALMO SALAR) BRAIN-PITUITARY-GONAD AXIS THROUGH REGULATION OF FSHB

Kjærner-Semb, Erik Nordtorp

2021

Long-term performance of gene edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition.

Lene Kleppe, Per Gunnar Fjelldal, Eva Andersson, Tom Johnny Hansen, Monica Sanden, Aina Bruvik, Kai Ove Skaftnesmo, Tomasz Furmanek, Erik Nordtorp Kjærner-Semb, Diego Crespo, Simon Flavell, Audun Ø. Pedersen, Petra Vogelsang, Anne Torsvik, Sara Olausson, Birgitta Norberg, Rüdiger W. Schulz, Jan Bogerd, Nina Santi, Rolf Brudvik Edvardsen, Anna Wargelius

2021

VGLL3A ALLELES AFFECT THE BRAIN-PITUITARY-GONAD AXIS IN ATLANTIC SALMON (SALMO SALAR) VIA REGULATION OF FSHB

Kjærner-Semb, Erik Nordtorp

2019

Exploring beneficial genetic variants in Atlantic salmon using gene editing

Erik Nordtorp Kjærner-Semb, Anna Wargelius, Rolf Brudvik Edvardsen

2018

VGLL3 AND THE HIPPO PATHWAY ARE REGULATED IN SERTOLI CELLS UPON ENTRY AND DURING PUBERTY IN ATLANTIC SALMON TESTIS.

2016

Genome resequencing shows adaptive divergence in Atlantic salmon

Kjærner-Semb, Erik Nordtorp

2015

The vgll3 locus controls time of maturity in salmon

Kjærner-Semb, Erik Nordtorp

Reports and dissertations

2022

FUNCTIONAL CHARACTERIZA TION OF GPR132 AND CADM1 AND THEIR POTENTIAL ROLES IN DISEASE RESISTANCE IN ATLANTIC SALMON (SALMO SALAR)

Marte Bårvåg Nesse, Anna Sofie Troedsson Wargelius, Erik Nordtorp Kjærner-Semb

2017

Genetics behind puberty and adaptation in Atlantic Salmon revealed by genomic studies

Anna Wargelius, Rolf Edvardsen, Erik Nordtorp Kjærner-Semb, Kevin Glover

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Erik Kjærner-Semb

Publications

Academic articles

Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification

Loss of bmp15 function in the seasonal spawner Atlantic salmon results in ovulatory failure

Highly efficient in vivo C-to-T base editing in Atlantic salmon (Salmo salar) – A step towards aquaculture precision breeding

Loss of Fshr Prevents Testicular Maturation in Atlantic Salmon (Salmo salar L.)

In vivo CRISPR/LbCas12a-mediated knock-in and knock-out in Atlantic salmon (Salmo salar L.)

Heterochiasmy and the establishment of gsdf as a novel sex determining gene in Atlantic halibut

Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies

Full production cycle performance of gene-edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition

Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors

Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon

Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere

Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon

The influence of vgll3 genotypes on sea age at maturity is altered in farmed mowi strain Atlantic salmon

Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis

Atlantic salmon populations reveal adaptive divergence of immune related genes - A duplicated genome under selection

The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon(Salmo salar L.) Males

Other journal contributions

Author Correction: Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon (Scientific Reports, (2020), 10, 1, (18042), 10.1038/s41598-020-74876-2)

Ulik laks i sør og nord

Scientific lectures

Knockout av vgll3 gir sein kjønnsmodning i hannlaks

Uses of biotechnology to control reproduction in Atlantic salmon

Moving sterile Crispr salmon from the tank to sea cages - regulatory barriers and social impacts

LACK OF VGLL3A DELAYS ONSET OF MALE MATURATION IN ATLANTIC SALMON

Lack of vgll3a Delays Onset of Male Maturation in Atlantic Salmon

Compensatory mechanism of NKAα1a in nkaα1b1/b2 Crispants during smoltification in Atlantic Salmon (Salmo salar)

Lack of vgll3a delays onset of sexual maturation in Atlantic salmon (Salmo salar) males

Kan genetiske tilpasninger i ferskvannlaks, avsløre genetikk bak smoltifisering?

Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification.

VGLL3A ALLELES AFFECT THE BRAIN-PITUITARY-GONAD AXIS IN ATLANTIC SALMON (SALMO SALAR) VIA REGULATION OF FSHB

Functional genomic analysis of landlocked Atlantic salmon (Salmo Salar) populations.

Development of gene editing technology and applications in Atlantic salmon

Hva er de genetiske forskjellene mellom ferskvannslaks og anadrom laks?.

Genomic regions under selection in landlocked Atlantic salmon. International Conference on Integrative Salmonid Biology

Highly efficient CRISPR/Cas9 knock-in in Atlantic salmon

Genomic regions under selection in landlocked Atlantic salmon

Hvordan fungerer laksens pubertetsgen?

Genome resequencing of geographically distinct Atlantic Salmon (Salmo salar) populations reveals adaptive divergence

Adaptive plasticity in Atlantic salmon- genetic predisposition of time at maturity and environmental triggers

The vgll3 locus controls time of maturation in salmon

Mario: Interactive Tuning of Biological Analysis Pipelines Using Iterative Processing

Poster

VGLL3A PÅVIRKER HJERNE-HYPOFYSE-GONADE AKSEN I ATLANTISK LAKS (SALMO SALAR) VIA REGULERING AV FSHB

VGLL3A CONNECTS TO THE ATLANTIC SALMON (SALMO SALAR) BRAIN-PITUITARY-GONAD AXIS THROUGH REGULATION OF FSHB

Long-term performance of gene edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition.

VGLL3A ALLELES AFFECT THE BRAIN-PITUITARY-GONAD AXIS IN ATLANTIC SALMON (SALMO SALAR) VIA REGULATION OF FSHB

Exploring beneficial genetic variants in Atlantic salmon using gene editing

VGLL3 AND THE HIPPO PATHWAY ARE REGULATED IN SERTOLI CELLS UPON ENTRY AND DURING PUBERTY IN ATLANTIC SALMON TESTIS.

Genome resequencing shows adaptive divergence in Atlantic salmon

The vgll3 locus controls time of maturity in salmon

Reports and dissertations

FUNCTIONAL CHARACTERIZA TION OF GPR132 AND CADM1 AND THEIR POTENTIAL ROLES IN DISEASE RESISTANCE IN ATLANTIC SALMON (SALMO SALAR)

Genetics behind puberty and adaptation in Atlantic Salmon revealed by genomic studies

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