Anna Wargelius
Arbeidsområde
GROUP LEADER
Reproduction and Developmental Biology
RESEARCH INTERESTS
Gene expression pattern and level reflects to a significant extent the ongoing anatomical, morphological and physiological activities in a tissue and/or organism. My field of interest is functional genomics in Atlantic salmon with focus on the reproductive mechanisms. We currently use CRISPR-Cas9 to knockout (KO) genes in Atlantic salmon (Edvardsen et al 2014), to be able to 1) explore molecular mechanisms related to the reproductive system, in particular germ cell specification and early sexual development, and we have recently produce germ cell free salmon by ablation of the primordial germ cells using CRISPR-Cas9 knockout of the dnd gene (PGCs, (Wargelius et al 2016). Both aims explore fields which can result in sterility models for aquaculture that could solve major bottlenecks related to un-wanted sexual maturation and genetic interactions with wild populations. Currently two of my projects are intensively exploring these fields, SALMOSTERILE 2013-2018 (NFR BIOTEK 2021 project, https://www.hi.no/salmosterile/nb-no ) and POSTSMOLTMAR (HAVBRUK 2 2016-2020).
We have also in recent years explored the wild genome pool of Atlantic salmon with the main aim to identify genetic regions under selection for primarily reproductive traits, such as time at maturity (Ayllon et al 2015) However studies have also revealed genetic regions /sweeps that probably confer traits associated with disease resistance, behaviour, sea water adaption and feed metabolism (Kjærner-Semb et al 2016). SALMAT 2013-2017 (NFR-BIOTEK 2021-HAVBRUK project), MATGEN 2016-2020 (NFR _HAVBRUK) and DIGISAL (Biotek2021-digital life)
Curriculum Vitae
Anna Sofie Troedsson-Wargelius (MSc, PhD)
Group leader, Principal Scientist (1183), Institute of Marine Research
DOB , 05.12.1972
Civil status Married, three children
FORMAL EDUCATION :
1998-2001 PhD Institute of Molecular Biology, University of Bergen, Norway
1991-1996 Master in Biology, University of Uppsala, Sweden
Publikasjoner
Vitenskapelige artikler (NVI)
2024
Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification
BMC Genomic Data
25
2024
Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification.
BMC Genomic Data
2024
Loss of bmp15 function in the seasonal spawner Atlantic salmon results in ovulatory failure
The FASEB Journal
38
2024
Loss of Fshr Prevents Testicular Maturation in Atlantic Salmon (Salmo salar L.)
Endocrinology
165
2022
Towards production of genome-edited aquaculture species
Reviews in Aquaculture
2022
Pituitary Gonadotropin Gene Expression During Induced Onset of Postsmolt Maturation in Male Atlantic Salmon: In Vivo and Tissue Culture Studies
Frontiers in Endocrinology
13
2022
Full production cycle performance of gene-edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition
Aquaculture
560
2022
Quantitative proteome profiling reveals molecular hallmarks of egg quality in Atlantic halibut: impairments of transcription and protein folding impede protein and energy homeostasis during early development
BMC Genomics
23
2022
The Piwil1 N domain is required for germ cell survival in Atlantic salmon
Frontiers in Cell and Developmental Biology
10
2021
Genome editing in food and feed production – implications for risk assessment. Scientific Opinion of the Scientific Steering Committee of the Norwegian Scientific Committee for Food and Environment
VKM Report
2021
2021
Single nucleotide replacement in the Atlantic salmon genome using CRISPR/Cas9 and asymmetrical oligonucleotide donors
BMC Genomics
22
2021
Genome editing in food and feed production – implications for risk assessment. Opinion of the Steering Committee of the Norwegian Scientific Committee for Food and Environment
VKM Report
2021:18
p. 1-291
2021
Loss of stra8 Increases Germ Cell Apoptosis but Is Still Compatible With Sperm Production in Atlantic Salmon (Salmo salar)
Frontiers in Cell and Developmental Biology
9
2021
Genome editing in food and feed production – implications for risk assessment
VKM Report
2021
RADSex: A computational workflow to study sex determination using restriction site- associated DNA sequencing data
Molecular Ecology Resources
21
p. 1715-1731
2021
Genome editing on finfish: Current status and implications for sustainability
Reviews in Aquaculture
p. 1-20
2020
Development of supermale and all-male Atlantic salmon to research the vgll3 allele - puberty link
BMC Genetics
21
2020
Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon
Scientific Reports
10
2020
Targeted mutagenesis of Δ5 and Δ6 fatty acyl desaturases induce dysregulation of lipid metabolism in Atlantic salmon (Salmo salar)
BMC Genomics
21
2020
Autosomal sdY pseudogenes explain discordances between phenotypic sex and DNA marker for sex identification in Atlantic salmon
Frontiers in Genetics
11
p. 1-10
2020
Comparison of anadromous and landlocked Atlantic salmon genomes reveals signatures of parallel and relaxed selection across the Northern Hemisphere
Evolutionary Applications
p. 1-16
2020
Transcriptomic analysis of dead end knockout testis reveals germ cell and gonadal somatic factors in Atlantic salmon
BMC Genomics
21
p. 1-15
2020
Indel locations are determined by template polarity in highly efficient in vivo CRISPR/Cas9- mediated HDR in Atlantic salmon
Scientific Reports
10
2019
CRISPR/Cas9-mediated editing of Δ5 and Δ6 desaturases impairs Δ8-desaturation and docosahexaenoic acid synthesis in Atlantic salmon (Salmo salar L.)
Scientific Reports
9
p. 1-13
2019
Application of genome editing in aquatic farm animals: Atlantic salmon
Transgenic research
28
p. 101-105
2019
Potential of genome editing to improve aquaculture breeding and production
Trends in Genetics
35
p. 672-684
2019
The influence of vgll3 genotypes on sea age at maturity is altered in farmed mowi strain Atlantic salmon
BMC Genetics
20:44
p. 1-8
2019
CRISPR/Cas9-mediated ablation of elovl2 in Atlantic salmon (Salmo salar L.) inhibits elongation of polyunsaturated fatty acids and induces Srebp-1 and target genes
Scientific Reports
9
p. 1-13
2018
Vgll3 and the Hippo pathway are regulated in Sertoli cells upon entry and during puberty in Atlantic salmon testis
Scientific Reports
8:1912
p. 1-11
2017
Integrative testis transcriptome analysis reveals differentially expressed miRNAs and their mRNA targets during early puberty in Atlantic salmon
BMC Genomics
18
2017
Sex steroid production associated with puberty is absent in germ cellfree salmon
Scientific Reports
7
2017
Rapid growth causes abnormal vaterite formation in farmed fish otoliths
Journal of Experimental Biology
220
p. 2965-2969
2017
Susceptibility, behaviour, and retention of the parasitic salmon louse (Lepeophtheirus salmonis) differ with Atlantic salmon population origin
Journal of Fish Diseases
41
p. 431-442
2017
Functional Annotation of All Salmonid Genomes (FAASG): an international initiative supporting future salmonid research, conservation and aquaculture
BMC Genomics
18
2017
bmp15l, figla, smc1bl, and larp6l are preferentially expressed in germ cells in Atlantic salmon (Salmo salar L.)
Molecular Reproduction and Development
84
p. 76-87
2016
Dnd knockout ablates germ cells and demonstrates germ cell independent sex differentiation in Atlantic salmon
Scientific Reports
6
2016
Atlantic salmon populations reveal adaptive divergence of immune related genes - A duplicated genome under selection
BMC Genomics
17:610
p. 1-12
2016
Increased dietary phosphorous prevents vertebral deformities in triploid Atlantic salmon (Salmo salar L.)
Aquaculture Nutrition
22
p. 72-90
2016
Approaches for delaying sexual maturation in salmon and their possible ecological and ethical implications
Journal of Applied Aquaculture
28
p. 330-369
2015
The vgll3 Locus Controls Age at Maturity in Wild and Domesticated Atlantic Salmon(Salmo salar L.) Males
PLoS Genetics
11:e1005628
2015
A comparison between egg trancriptomes of cod and salmon reveals species-specific traits in eggs for each species
Molecular Reproduction and Development
82
p. 397-404
2015
Gonad specific genes in Atlantic salmon (Salmon salar L.): Characterization of tdrd7-2, dazl-2, piwil1 and tdrd1 genes
Gene
560
p. 217-225
2014
Global transcriptome analysis identifies regulated transcripts and pathways activated during oogenesis and early embryogenesis in atlantic cod
Molecular Reproduction and Development
81
p. 619-635
2014
Targeted mutagenesis in Atlantic salmon(Salmo salar L.)Using the CRISPR/Cas9 system induces Complete knockout individuals in the F0 generation
PLOS ONE
9
p. 1-7
2014
Transcriptome sequencing of Atlantic salmon (Salmo salar L.) notochord prior to development of the vertebrae provides clues to regulation of positional fate, chordoblast lineage and mineralisation
BMC Genomics
15:141
2013
Mineralization of the vertebral bodies in Atlantic salmon (Salmo salar L.) is initiated segmentally in the form of hydroxyapatite crystal accretions in the notochord sheath
Journal of Anatomy
223
p. 159-170
2013
Cortisol treatment of prespawning female cod affects cytogenesis related factors in eggs and embryos
General and Comparative Endocrinology
189
p. 84-95
2012
Maternal 3 ' UTRs: from egg to onset of zygotic transcription in Atlantic cod
BMC Genomics
13
2012
Dietary phosphorus does not reduce the risk for spinal deformities in a model of adjuvant-induced inflammation in Atlantic salmon (Salmo salar) postsmolts
Aquaculture Nutrition
18
p. 12-20
2012
Stress and expression of cyclooxygenases (cox1, cox2a, cox2b) and intestinal eicosanoids, in Atlantic salmon
Fish Physiology & Biochemistry
38
p. 951-962
2012
Continuous light induces bone resorption and affects vertebral morphology in Atlantic salmon (Salmo salar L.) fed a phosphorous deficient diet
Aquaculture Nutrition
18
p. 610-619
2012
Vertebral deformities in farmed Atlantic salmon (Salmo salar L.) - etiology and pathology
Journal of Applied Ichthyology
28
p. 433-440
2011
Sustained swimming increases the mineral content and osteocyte density of salmon vertebral bone
Journal of Anatomy
219
p. 490-501
2011
The effect of water temperature on vertebral deformities and vaccine-induced abdominal lesions in Atlantic salmon, Salmo salar L
Journal of Fish Diseases
34
p. 531-546
2011
Identification of vimentin- and elastin-like transcripts specifically expressed in developing notochord of Atlantic salmon (Salmo salar L.)
Cell and Tissue Research
346
p. 191-202
2010
Effects of vegetable feed ingredients on bone health in Atlantic salmon
Journal of Applied Ichthyology
26
p. 327-333
2010
Dietary fatty acids and inflammation in the vertebral column of Atlantic salmon, Salmo salar L., smolts: a possible link to spinal deformities
Journal of Fish Diseases
33
p. 957-972
2010
MMP-13 (Matrix MetalloProteinase 13) expression might be an indicator for increased ECM remodeling and early signs of vertebral compression in farmed Atlantic salmon (Salmo salar L.)
Journal of Applied Ichthyology
26
p. 366-371
2010
Collagen type XI alpha 1 may be involved in the structural plasticity of the vertebral column in Atlantic salmon (Salmo salar L.)
Journal of Experimental Biology
213
p. 1207-1216
2009
Continuous light affects mineralization and delays osteoid incorporation in vertebral bone of Atlantic salmon (Salmo Salar L.)
Journal of Experimental Biology
212
p. 656-661
2009
Differential gene expression of bgp and mgp in trabecular and compact bone of Atlantic salmon (Salmo salar L.) vertebrae
Journal of Anatomy
215
p. 663-672
2009
Dietary menadione nicotinamide bisulphite (vitamin K-3) does not affect growth or bone health in first-feeding fry of Atlantic salmon (Salmo salar L.)
Aquaculture Nutrition
15
p. 638-649
2007
Molecular mechanisms of contiuous light inhibition of Atlantic salmon parr-smolt transformation
Aquaculture
273
p. 235-245
2007
Molecular mechanisms of continuous light inhibition of Atlantic salmon parr-smolt transformation
Aquaculture
273
p. 235-245
2006
Growth hormone and insulin-like growth factor-I act together and independently when regulating growth in vertebral and muscle tissue of Atlantic salmon postsmolts
General and Comparative Endocrinology
149
p. 253-260
2006
Insight into the complex genetic network of tetraploid Atlantic salmon (Salmo salar L.): Description of multiple novel Pax7 splice variants
Gene
373
p. 8-15
2005
A peak in gh-receptor expression is associated with growth activation in Atlantic salmon vertebrae, while upregulation of igf-I receptor expression is related to increased bone density
General and Comparative Endocrinology
142
p. 163-168
2005
Heat shock during early somitogenesis induces caudal vertebral column defects in Atlantic salmon (Salmo salar)
Development, Genes and Evolution
215
p. 350-357
2005
Vertebrae of the trunk and tail display different growth rates in response to photoperiod in Atlantic salmon, Salmo salar L., post-smolts
Aquaculture
250
p. 516-524
2004
Influence of egg vitamin A status and egg incubation temperature on subsequent development of the early vertebral column in Atlantic salmon (Salmo salar L.) fry
Journal of Fish Biology
64
p. 399-417
2004
Spring growth in the vertebrae of Atlantic salmon (Salmo salar) is characterized by a gradual increase in ihh expression, while a certain photoperiod triggers shh induction
Journal of Bone and Mineral Research
19
p. 217
2004
Influence of egg vitamin A status and egg incubation temperature on subsequent development of the early vertebral column in Atlantic salmon fry
Journal of Fish Biology
64
p. 399-417
2003
Retinal expression of zebrafish six3.1 and its regulation by Pax6
Biochemical and Biophysical Research Communications - BBRC
309
p. 475-481
2001
RNA interference: mechanisms and applications
Biotechnology Annual Review
7
p. 31-57
2000
Fas and Fas ligand gene polymorphisms in primary Sjögren's syndrome
Journal of Rheumatology
27
p. 2397-2405
2000
Fas and Fas ligand gene polymorphisms in primary Sjögren's syndrome
Journal of Rheumatology
27
p. 2397-2405
1999
Double-stranded RNA induces specific developmental defects in Zebrafish Embryos
Biochemical and Biophysical Research Communications - BBRC
263
p. 156-161
1999
Double-Stranded RNA Induces Specific Developmental Defects in Zebrafish Embryos
Biochemical and Biophysical Research Communications - BBRC
263
p. 156-161
Annet tidsskriftbidrag
2023
GMO-regler må ikke få stoppe utviklingen av avanserte terapier
Dagens medisin
2023
På tide å åpne for genteknologi i norsk matproduksjon
Nationen
2023
Uetisk å la være å satse på genteknologi
Dagsavisen
2023
Mer faglighet fra naturbevegelsen, takk
Klassekampen
2021
Author Correction: Rescue of germ cells in dnd crispant embryos opens the possibility to produce inherited sterility in Atlantic salmon (Scientific Reports, (2020), 10, 1, (18042), 10.1038/s41598-020-74876-2)
Scientific Reports
11
2016
Ulik laks i sør og nord
Dagens næringsliv
Faglige foredrag
2024
Transkriptomikk og genredigering som verktøy for å utforske genetiske mekanismer som kan gi artsspesifkk resistens mot lakselus
2024
Use of transcriptomics and gene editing to explore genetic mechanisms giving species-specific host-resistance to sea lice
2024
Uses of biotechnology to control reproduction in Atlantic salmon
2024
A perspective on potential uses of gene editing in salmon breeding and production.
2024
Gene Editing in Aquaculture: From Sustainable Solutions to Regulatory Barriers
2024
Moving sterile Crispr salmon from the tank to sea cages - regulatory barriers and social impacts
2024
Søknad om forsøksutsetting av genredigert steril laks
2023
Compensatory mechanism of NKAα1a in nkaα1b1/b2 Crispants during smoltification in Atlantic Salmon (Salmo salar)
2022
Kan genetiske tilpasninger i ferskvannlaks, avsløre genetikk bak smoltifisering?
2022
Adaptation in landlocked Atlantic salmon links genetics in wild and farmed salmon to smoltification.
2022
VGLL3A ALLELES AFFECT THE BRAIN-PITUITARY-GONAD AXIS IN ATLANTIC SALMON (SALMO SALAR) VIA REGULATION OF FSHB
2021
Functional genomic analysis of landlocked Atlantic salmon (Salmo Salar) populations.
2020
Hva er de genetiske forskjellene mellom ferskvannslaks og anadrom laks?.
2019
Genomic regions under selection in landlocked Atlantic salmon. International Conference on Integrative Salmonid Biology
2019
Highly efficient CRISPR/Cas9 knock-in in Atlantic salmon
2019
Highly efficient CRISPR/Cas9 knock-in in Atlantic Salmon
2019
Genomic regions under selection in landlocked Atlantic salmon
2018
None
2018
Hvordan fungerer laksens pubertetsgen?
2018
Optimization of CRISPR/Cas9 knock-in technology and application in salmon
2017
Gene editing a possible way to solve major sustainability issues in Atlantic salmon farming?
2017
Gene editing - adressing major sustainability issues in Atlantic salmon farming
2017
Gene editing. A game changer for aquaculture.
2017
The search for sustainable solution for coexistence but not mixing of farmed and wild salmon strains: Gene-editing to the rescue?
2016
Targeting germ cell survival factors to produce sterile salmon
2016
Targeting germ cell survival factors to produce sterile salmon through vaccination
2016
Sterile salmon by targeting factors involved in germ cell survival: novel strategies for sustainable fish farming
2016
Functional studies in Atlantic salmon (Salmo salar L) reveals candidates for sterility vaccines.
2016
Targeted mutagenesis in Atlantic salmon using the CRISPR/Cas9 system
2016
Bruk av CRISPR/Cas9 i laks
2016
Genome resequencing of geographically distinct Atlantic Salmon (Salmo salar) populations reveals adaptive divergence
2016
Adaptive plasticity in Atlantic salmon- genetic predisposition of time at maturity and environmental triggers
2015
Identification of novel sterility vaccine candidates, in RNAseq samples of Atlantic salmon testis.
2015
Reproductive constraints in salmon aquaculture using genomics
2014
A comparison between egg trancriptomes of cod and salmon reveals species specific traits in eggs for each species
2014
APPLICATIONS OF GENOME-WIDE TECHNIQUES TO STUDY SALMON PHYSIOLOGY, DEVELOPMENT AND REPRODUCTION
2013
GLOBAL TRANSCRIPTOME ANALYSIS IDENTIFIES REGULATED TRANSCRIPTS AND PATHWAYS ACTIVATED DURING OOGENESIS AND EARLY EMBRYOGENESIS IN ATLANTIC COD
2013
DEEP SEQUENCING REVEALS MINERALIZING NOTOCHORD TRANSCRIPTOME, DURING AXIAL SKELETON ENFORCEMENT FROM NOTOCHORD TO VERTEBRA IN ATLANTIC SALMON (SALMO SALAR L.)
2013
GLOBAL AND LOCAL METHYLATION PATTERN IN TRIPLOID AND DIPLOID AND TRIPLOID ATLANTIC SALMON
2012
Attempts to induce sterility in Atlantic salmon by morfolino and zink finger techniques
2012
The Atlantic salmon (Salmo Salar L.) notochord displays a dynamic transcriptome prior to and during vertebral segmentation
2012
Knockdown of salmon dead-end affect gonad morphology in 10 months old Atlantic salmon (Salmo Salar L.)
2011
Maternal 3'UTRs: from egg to onset of zygotic transcription in Atlantic cod
2011
Control of sexual maturity in cod farming – status and future solution
2010
Continuous light induces bone resorption and affects vertebral morphology in Atlantic salmon (Salmo salar L.) fed a phosphorous deficient diet
2009
Dietary Fatty Acids and Inflammation in the vertebral column of Atlantic salmon (Salmo salar) smolts: A possible link to spinal deformities
2009
Deformations of the spinal column in Atlantic salmon
2008
Inflammation as a risk factor for spinal deformities in farmed Atlantic salmon (Salmo salar) 0+ smolts
2005
Elevated retinol levels do not cause spinal deformities in the developing salmon embryo
1998
Detection of polymorphisms in the genes encoding Fas and Fas ligand in patients with primary Sjögren´s syndrome
1998
Detection of polymorphisms in the genes encoding Fas and Fas ligand in patients with primary Sjögren's syndrome
1997
Screening for mutations in the fas gene in patientes with primary Sj@øgren's syndrome
Poster
2021
Long-term performance of gene edited, sterile Atlantic salmon - growth, smoltification, welfare indicators and fillet composition.
2019
Exploring beneficial genetic variants in Atlantic salmon using gene editing
2018
VGLL3 AND THE HIPPO PATHWAY ARE REGULATED IN SERTOLI CELLS UPON ENTRY AND DURING PUBERTY IN ATLANTIC SALMON TESTIS.
2017
Triploid salmon - susceptibility to infectious viral diseases
2016
Differences among Atlantic salmon biologies in their susceptibility and behavioural response to infective sealice, Leperophtheirus salmonis, and the retention of lice.
2015
SCREENING FOR STERILITY CANDIDATE GENES IN ATLANTIC SALMON (SALMO SALAR)
2014
Candidate genes for sterility in Atlantic salmon (Salmo salar)
2014
SMALL RNAS IN IMMATURE AND MATURE TESTIS OF ATLANTIC SALMON (SALMO SALAR L.)
2013
Radiological studies on vertebral deformities in triploid Atlantic salmon (Salmo salar)
2011
The link between broodstock stress and offspring developmental potential in Atlantic cod Gadus morhua L
2008
Inflammation as a risk factor for spinal deformities in farmed Atlantic salmon underyearling smolts
2008
Dietary menadione nicotinamide bisulphite (vitamin K) does not affect growth or bone health in first feeding Atlantic salmon (Salmo salar)
2007
Investigations on first feeding fry of Atlantic salmon (Salmo salar L.) fed diets with different levels of menadione nicotinamide bisulphite (MNB)
2007
Nutritional status of Atlantic salmon (Salmo salar) broodstock- A preliminary study on the maternal effects on early expression of leptin, IGF-I, IGF-IR, GH and GHR
1998
A retroviral vector (MSCV) injected at distinct stages of development in zebrafish embryos
Rapporter og avhandlinger
2023
Genteknologi i en bærekraftig fremtid
2022
FUNCTIONAL CHARACTERIZA TION OF GPR132 AND CADM1 AND THEIR POTENTIAL ROLES IN DISEASE RESISTANCE IN ATLANTIC SALMON (SALMO SALAR)
2017
Genetics behind puberty and adaptation in Atlantic Salmon revealed by genomic studies
2015
Endrer gener for å få steril fisk
2001
A study of Six3-like genes involved in zebrafish eye and forebrain development
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